Prof. Dr Jzef Dulak
Prof. Dr. Józef Dulak is Professor and Head of the Department of Medical Biotechnology at the Faculty of Biochemistry, Biophysics and Biotechnology of the Jagiellonian University in Kraków. He is a member of the Polish Academy of Sciences (PAN), the Polish Academy of Arts and Sciences (PAU), and Academia Europaea, and serves as Vice-Chairman of the Committee of Biotechnology of the Polish Academy of Sciences.
His research focuses on molecular mechanisms of cardiovascular and genetic neuromuscular diseases, including Duchenne muscular dystrophy (DMD) and laminin-α2-deficient congenital muscular dystrophy (LAMA2-MD). He has made important contributions to understanding nitric oxide–dependent regulation of angiogenesis and the role of Nrf2 and heme oxygenase-1 (HO-1) in tissue injury and regeneration.
More recently, his group has developed iPSC-based models of LAMA2-MD and applied CRISPR/Cas gene editing to investigate disease mechanisms and therapeutic strategies. This work culminated in a recent publication in Nature Communications, led by the team of Prof. Markus Rüegg and performed in close collaboration with Prof. Dulak’s group, elucidating novel molecular pathways in laminin-α2 deficiency. His work has significantly advanced the fields of vascular biology, redox signaling, and translational research in neuromuscular disorders